The U.S. collagen marketplace dimension used to be estimated at greater than $2.11 billion in 2022 and is expected to make bigger at a compound annual enlargement charge (CAGR) of eleven.2 p.c from 2023 to 2030.1 Obviously, collagen is a taking place nutritional complement class—and should you’ve been within the {industry} for some time, you’re most likely mindful that the main makes use of of collagen are for pores and skin and joint well being. However all collagen fabrics aren’t created equivalent. They don’t all have the similar resources, and their advantages, resources and dosage ranges aren’t the similar both. On this article, I’m going to talk about one of the most variations between to be had collagen fabrics. Let’s get started by means of defining collagen.
Collagen Outlined
Collagen is the principle structural protein discovered within the pores and skin and different connective tissues. This protein is important to our just right well being. It makes up 25 p.c to 35 p.c of the whole-body protein content material. At the side of a few different key structural proteins, collagen is accountable for pores and skin energy and elasticity. When collagen degrades, it ends up in the wrinkles that accompany getting older, in addition to numerous different problems.
As with all protein, collagen is made from amino acids. When it comes to collagen, there’s a in particular prime focus of hydroxyproline. This prime focus does now not have a tendency to happen in really extensive amounts in different proteins.2 On the identical time, collagen has little or no tryptophan. In consequence, it’s not regarded as to be an entire protein, and so can’t be counted as contributing to the proportion Day-to-day Worth for protein within the Complement Info panel of a nutritional complement. It will have to even be famous that collagen is located solely in people and different animals. It isn’t present in plant proteins. Subsequently, there’s no “vegan collagen,” despite the fact that I’m mindful of a few vegan amino acid blends that emulate the construction of collagen.
Collagen Resources and Sorts
There are various kinds of collagens within the physique. This comprises collagen kind 1, kind 2 and kind 3. There are any other varieties as smartly, however they aren’t related within the context of this dialog. Kind 1 is essentially the collagen present in pores and skin, tendons, veins/arteries, and bone. Kind 2 is essentially present in cartilage, despite the fact that some is located within the pores and skin. Kind 3 is a fibrous type of collagen discovered along kind 1.
Meals resources of collagen come with animal proteins corresponding to red meat, rooster, beef and fish (so long as you come with the surface). As well as, broth comprised of red meat bones could also be a just right supply of collagen—despite the fact that common intake of such red meat broth may additionally yield a higher-than-average quantity of lead since lead has a tendency to deposit within the bones. The truth is, you’re getting your collagen from high quality nutritional dietary supplements to guarantee right kind quantities and to steer clear of unwanted quantities of lead.
Talking of which, red meat, rooster, beef and fish all function business resources of collagen fabrics utilized in nutritional dietary supplements. Those paperwork are common provide as collagen peptides—small chains of collagen protein which were damaged down (hydrolyzed) from higher collagen protein chains. Those smaller collagen peptide chains are higher absorbed. There could also be an eggshell membrane supply of collagen.
Bovine (Pork)-derived Collagen Peptides
Studies3,4 point out that, in comparison to placebo, 2.5 g/day of a selected bovine-derived collagen peptide subject matter (Verisol) considerably lowered eye wrinkle quantity by means of 20 p.c (p<0.05), larger content material of procollagen kind I (65 p.c), elastin (18 p.c) and fibrillin (6 p.c), progressed pores and skin elasticity (p<0.05) and certainly influenced pores and skin moisture. Further research5,6 confirmed that 2.5 g of Veriso resulted in a statistically important lower within the stage of cellulite and a discounted pores and skin waviness on thighs (i.e., a measure of pores and skin smoothness, or lack thereof) (p<0.05), and in addition considerably larger hair thickness (p<0.01) and larger hair cellular proliferation charge by means of 31 p.c (p<0.01). Verisol predominantly supplies kind 1 and three collagen. This subject matter is acceptable to be used in powders because it dissolves well and has a impartial style profile.
Rooster-derived Collagen Extract
Research7 indicated that 1 g/day of Biocell, a selected kind 2 collagen extract (from rooster sternal cartilage), resulted in an important relief of pores and skin dryness/scaling (76 p.c, P = 0.002) and world strains/wrinkles (13.2 p.c, P = 0.028), in addition to an important building up within the content material of hemoglobin (15 p.c, P = 0.008) within the pores and skin epidermis has been proven to cut back pores and skin dryness, strains/wrinkles, and larger collagen with 1,000 mg/day, and toughen wholesome joints with 2,000 mg/day.8 At find out about at 2 g/day demonstrated that, in comparison to placebo, Biocell resulted in an important lower in osteoarthritis ache on each days 35 (p = 0.017) and 70 (p < 0.001) in addition to an important growth in bodily actions. This subject matter will have to be restricted to pills and drugs because it does now not have a just right style profile.
Fish Collagen Peptides (i.e., “Marine Collagen”)
Research9 has demonstrated that 5 g/day of a selected fish collagen peptide from Wellnex, reduced the surface house of UV spots 11.67 p.c by means of 8 weeks after ingestion (p=0.034). Any other study10 discovered that 5 g/day of fish collagen peptides larger hair shaft diameter (i.e., hair thickness) by means of 44 p.c in comparison to placebo. A 3rd study11 the usage of 5 g/day of fish collagen peptides confirmed important 200 p.c building up (share distinction) over placebo in facial pores and skin moisture (p<0.005) and an important 114 p.c lower (share distinction) over placebo in roughness (p<0.005). This subject matter is acceptable to be used in powders because it has a impartial style profile.
Eggshell Membrane Collagen
Ovoderm is a nutraceutical got from eggshell membranes that incorporates naturally happening collagen and glycosaminoglycans, corresponding to hyaluronic acid. Research12-14 has demonstrated that 300 mg/day of Ovoderm resulted in a statistically important growth in pores and skin elasticity (12 p.c building up, p=0.0136), a bent to cut back pores and skin pigmentation (5 p.c lower), a 43 p.c of decline within the transepidermal water loss, progressed firmness and pores and skin fatigue by means of 33 p.c and 45 p.c increased than within the placebo remedy. Likewise, 300 mg of Ovomet (egg membrane, aka Ovoderm) brought about a gentle and statistically important relief in ache and stiffness depth and progressed the useful capability in osteoarthritis sufferers.15,16 This subject matter will have to be restricted to pills and drugs. Even though it doesn’t have a foul style, in keeping with se, it doesn’t in reality dissolve smartly.
Conclusion
For the sake of brevity, I’ve handiest indexed one instance every of collagen fabrics from bovine, rooster, fish and eggshell membrane resources. I determined now not to talk about porcine (beef) resources of collagen since it’s typically regarded as the least fascinating of the aforementioned (despite the fact that now not from an efficacy viewpoint). That being stated, the fabrics I did talk about on this article are handiest the top of the collagen iceberg. Every of those collagen fabrics have their very own distinct benefits and dosage ranges. Bovine collagen peptides are nice for pores and skin and hair at a 2.5 g dose. Collagen from rooster sternal cartilage is efficacious for pores and skin and joints at 1 and a pair of g doses, respectively. Fish collagen peptides are just right for pores and skin at a 5 g dose. In spite of everything, the eggshell membrane subject matter demonstrated advantages for pores and skin and joints at a dose of 300 mg. In assessing the choices to be used on your nutritional complement logo, don’t omit to imagine the dosage shape (e.g., drugs, pills, powders), and whether or not or now not the collagen subject matter you’re making an allowance for is acceptable. VR
References:
1 U.S. Collagen Marketplace Dimension, Percentage & Tendencies Research File Via Supply Kind, Via Product Kind (Gelatin, Hydrolyzed, Local), Via Software Kind, And Section Forecasts, 2023 – 2030. Grand View Analysis. Retrieved September 26, 2023 from www.grandviewresearch.com/industry-analysis/us-collagen-market-report#:~:textual content=The p.c.
2 Eastoe JE. The amino acid composition of mammalian collagen and gelatin. Biochem J. 1955 Dec; 61(4): 589–600.
3 Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral consumption of particular bioactive collagen peptides reduces pores and skin wrinkles and will increase dermal matrix synthesis. Pores and skin Pharmacol Physiol. 2014;27(3):113-9.
4 Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of particular collagen peptides has recommended results on human pores and skin body structure: a double-blind, placebo-controlled find out about. Pores and skin Pharmacol Physiol. 2014;27(1):47-55.
5 Schunck M, Zague V, Oesser S, Proksch E. Nutritional Supplementation with Particular Collagen Peptides Has a Frame Mass Index-Dependent Really helpful Impact on Cellulite Morphology. J Med Meals. 2015 Dec;18(12):1340-8.
6 Oesser S. The oral consumption of particular Bioactive Collagen Peptides has a favorable impact on hair thickness. Nutrafoods (2020) 1:134-138.
7 Schwartz SR, Park J. Ingestion of BioCell Collagen(®), a unique hydrolyzed rooster sternal cartilage extract; enhanced blood microcirculation and lowered facial getting older indicators. Clin Interv Growing old. 2012;7:267-73.
8 Schwartz SR1, Park J. Ingestion of BioCell Collagen(®), a unique hydrolyzed rooster sternal cartilage extract; enhanced blood microcirculation and lowered facial getting older indicators. Clin Interv Growing old. 2012;7:267-73.
9 Sugihara F, Inoue N. Medical results of collagen hydrolysates ingestion on UV-induced pigmented spots of human pores and skin: A initial find out about. Well being Sciences. 2012;28(2):153-156.
10 Saito N, Tamura T, Morikawa R, Kurihara Ok, Katsuoka Ok. Protection of Meals Containing 5000mg of Collagen Peptide and Its Impact on Hair in Well being Feminine Topics. Aesthet Dermatol. 2008;18:311-320.
11 Koizumi S, Inouse N, Sugihara F. The consequences of collagen hydrolysates derived from tilapia scales or pores and skin on human facial pores and skin. Jap Pharmacology and Therapeutics. 2019; 47(1):57-63.
12 Aguirre A, Gil-Quintana E, Fenaux M, et al. Really helpful Results of Oral Supplementation with Ovoderm on Human Pores and skin Body structure: Two Pilot Research, Magazine of Nutritional Dietary supplements. 2017; DOI: 10.1080/19390211.2017.1310781.
13 Gil-Quintana E, L. a. Nuez M, Aquirre A. Supplementation with Ovoderm Reduces the Medical Indicators of Pores and skin Growing old. A Double-Blind, Placebo-Managed Find out about. Clin Res Dermatol Open Get right of entry to. 2018; 5(2):1-8.
14 Aguirre A, Gil-Quintana E, L. a. Nuez M. Ovoderm an efficient remedy to give a boost to pores and skin situation in sufferers with altered pores and skin barrier serve as. Pores and skin. 2018;2(1):11-14.
15 Blasco JM-I, Aguirre A, Gil-Quintana E, Fenaux M. The impact of day-to-day management of 300 mg of ovomet for remedy of arthritis in aged sufferers. Int J Clin Rheumatol. 2016; 11(5), 77-81.
16 Gil-Quintana E, Fenaux M, L Nuez M, et al. Brief-Time period Results of Ovomet, Eggshell Membrane, in Joint Ache: A Double-Blind and Placebo Find out about. J Osteopor Phys Act. 2018; 6(1):211.
Gene Bruno, MS, MHS, Professor Emiritus of Nutraceutical Science, is a nutritionist, herbalist, creator and educator. For greater than 40 years he has skilled and educated herbal product outlets and well being care pros, has researched and formulated herbal merchandise for dozens of nutritional complement firms, and has written articles on diet, natural medication, nutraceuticals and integrative well being problems for business, client magazines and peer-reviewed publications. He will also be reached at eugenejbruno@gmail.com.
The U.S. collagen marketplace dimension used to be estimated at greater than $2.11 billion in 2022 and is expected to make bigger at a compound annual enlargement charge (CAGR) of eleven.2 p.c from 2023 to 2030.1 Obviously, collagen is a taking place nutritional complement class—and should you’ve been within the {industry} for some time, you’re most likely mindful that the main makes use of of collagen are for pores and skin and joint well being. However all collagen fabrics aren’t created equivalent. They don’t all have the similar resources, and their advantages, resources and dosage ranges aren’t the similar both. On this article, I’m going to talk about one of the most variations between to be had collagen fabrics. Let’s get started by means of defining collagen.
Collagen Outlined
Collagen is the principle structural protein discovered within the pores and skin and different connective tissues. This protein is important to our just right well being. It makes up 25 p.c to 35 p.c of the whole-body protein content material. At the side of a few different key structural proteins, collagen is accountable for pores and skin energy and elasticity. When collagen degrades, it ends up in the wrinkles that accompany getting older, in addition to numerous different problems.
As with all protein, collagen is made from amino acids. When it comes to collagen, there’s a in particular prime focus of hydroxyproline. This prime focus does now not have a tendency to happen in really extensive amounts in different proteins.2 On the identical time, collagen has little or no tryptophan. In consequence, it’s not regarded as to be an entire protein, and so can’t be counted as contributing to the proportion Day-to-day Worth for protein within the Complement Info panel of a nutritional complement. It will have to even be famous that collagen is located solely in people and different animals. It isn’t present in plant proteins. Subsequently, there’s no “vegan collagen,” despite the fact that I’m mindful of a few vegan amino acid blends that emulate the construction of collagen.
Collagen Resources and Sorts
There are various kinds of collagens within the physique. This comprises collagen kind 1, kind 2 and kind 3. There are any other varieties as smartly, however they aren’t related within the context of this dialog. Kind 1 is essentially the collagen present in pores and skin, tendons, veins/arteries, and bone. Kind 2 is essentially present in cartilage, despite the fact that some is located within the pores and skin. Kind 3 is a fibrous type of collagen discovered along kind 1.
Meals resources of collagen come with animal proteins corresponding to red meat, rooster, beef and fish (so long as you come with the surface). As well as, broth comprised of red meat bones could also be a just right supply of collagen—despite the fact that common intake of such red meat broth may additionally yield a higher-than-average quantity of lead since lead has a tendency to deposit within the bones. The truth is, you’re getting your collagen from high quality nutritional dietary supplements to guarantee right kind quantities and to steer clear of unwanted quantities of lead.
Talking of which, red meat, rooster, beef and fish all function business resources of collagen fabrics utilized in nutritional dietary supplements. Those paperwork are common provide as collagen peptides—small chains of collagen protein which were damaged down (hydrolyzed) from higher collagen protein chains. Those smaller collagen peptide chains are higher absorbed. There could also be an eggshell membrane supply of collagen.
Bovine (Pork)-derived Collagen Peptides
Studies3,4 point out that, in comparison to placebo, 2.5 g/day of a selected bovine-derived collagen peptide subject matter (Verisol) considerably lowered eye wrinkle quantity by means of 20 p.c (p<0.05), larger content material of procollagen kind I (65 p.c), elastin (18 p.c) and fibrillin (6 p.c), progressed pores and skin elasticity (p<0.05) and certainly influenced pores and skin moisture. Further research5,6 confirmed that 2.5 g of Veriso resulted in a statistically important lower within the stage of cellulite and a discounted pores and skin waviness on thighs (i.e., a measure of pores and skin smoothness, or lack thereof) (p<0.05), and in addition considerably larger hair thickness (p<0.01) and larger hair cellular proliferation charge by means of 31 p.c (p<0.01). Verisol predominantly supplies kind 1 and three collagen. This subject matter is acceptable to be used in powders because it dissolves well and has a impartial style profile.
Rooster-derived Collagen Extract
Research7 indicated that 1 g/day of Biocell, a selected kind 2 collagen extract (from rooster sternal cartilage), resulted in an important relief of pores and skin dryness/scaling (76 p.c, P = 0.002) and world strains/wrinkles (13.2 p.c, P = 0.028), in addition to an important building up within the content material of hemoglobin (15 p.c, P = 0.008) within the pores and skin epidermis has been proven to cut back pores and skin dryness, strains/wrinkles, and larger collagen with 1,000 mg/day, and toughen wholesome joints with 2,000 mg/day.8 At find out about at 2 g/day demonstrated that, in comparison to placebo, Biocell resulted in an important lower in osteoarthritis ache on each days 35 (p = 0.017) and 70 (p < 0.001) in addition to an important growth in bodily actions. This subject matter will have to be restricted to pills and drugs because it does now not have a just right style profile.
Fish Collagen Peptides (i.e., “Marine Collagen”)
Research9 has demonstrated that 5 g/day of a selected fish collagen peptide from Wellnex, reduced the surface house of UV spots 11.67 p.c by means of 8 weeks after ingestion (p=0.034). Any other study10 discovered that 5 g/day of fish collagen peptides larger hair shaft diameter (i.e., hair thickness) by means of 44 p.c in comparison to placebo. A 3rd study11 the usage of 5 g/day of fish collagen peptides confirmed important 200 p.c building up (share distinction) over placebo in facial pores and skin moisture (p<0.005) and an important 114 p.c lower (share distinction) over placebo in roughness (p<0.005). This subject matter is acceptable to be used in powders because it has a impartial style profile.
Eggshell Membrane Collagen
Ovoderm is a nutraceutical got from eggshell membranes that incorporates naturally happening collagen and glycosaminoglycans, corresponding to hyaluronic acid. Research12-14 has demonstrated that 300 mg/day of Ovoderm resulted in a statistically important growth in pores and skin elasticity (12 p.c building up, p=0.0136), a bent to cut back pores and skin pigmentation (5 p.c lower), a 43 p.c of decline within the transepidermal water loss, progressed firmness and pores and skin fatigue by means of 33 p.c and 45 p.c increased than within the placebo remedy. Likewise, 300 mg of Ovomet (egg membrane, aka Ovoderm) brought about a gentle and statistically important relief in ache and stiffness depth and progressed the useful capability in osteoarthritis sufferers.15,16 This subject matter will have to be restricted to pills and drugs. Even though it doesn’t have a foul style, in keeping with se, it doesn’t in reality dissolve smartly.
Conclusion
For the sake of brevity, I’ve handiest indexed one instance every of collagen fabrics from bovine, rooster, fish and eggshell membrane resources. I determined now not to talk about porcine (beef) resources of collagen since it’s typically regarded as the least fascinating of the aforementioned (despite the fact that now not from an efficacy viewpoint). That being stated, the fabrics I did talk about on this article are handiest the top of the collagen iceberg. Every of those collagen fabrics have their very own distinct benefits and dosage ranges. Bovine collagen peptides are nice for pores and skin and hair at a 2.5 g dose. Collagen from rooster sternal cartilage is efficacious for pores and skin and joints at 1 and a pair of g doses, respectively. Fish collagen peptides are just right for pores and skin at a 5 g dose. In spite of everything, the eggshell membrane subject matter demonstrated advantages for pores and skin and joints at a dose of 300 mg. In assessing the choices to be used on your nutritional complement logo, don’t omit to imagine the dosage shape (e.g., drugs, pills, powders), and whether or not or now not the collagen subject matter you’re making an allowance for is acceptable. VR
References:
1 U.S. Collagen Marketplace Dimension, Percentage & Tendencies Research File Via Supply Kind, Via Product Kind (Gelatin, Hydrolyzed, Local), Via Software Kind, And Section Forecasts, 2023 – 2030. Grand View Analysis. Retrieved September 26, 2023 from www.grandviewresearch.com/industry-analysis/us-collagen-market-report#:~:textual content=The p.c.
2 Eastoe JE. The amino acid composition of mammalian collagen and gelatin. Biochem J. 1955 Dec; 61(4): 589–600.
3 Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral consumption of particular bioactive collagen peptides reduces pores and skin wrinkles and will increase dermal matrix synthesis. Pores and skin Pharmacol Physiol. 2014;27(3):113-9.
4 Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of particular collagen peptides has recommended results on human pores and skin body structure: a double-blind, placebo-controlled find out about. Pores and skin Pharmacol Physiol. 2014;27(1):47-55.
5 Schunck M, Zague V, Oesser S, Proksch E. Nutritional Supplementation with Particular Collagen Peptides Has a Frame Mass Index-Dependent Really helpful Impact on Cellulite Morphology. J Med Meals. 2015 Dec;18(12):1340-8.
6 Oesser S. The oral consumption of particular Bioactive Collagen Peptides has a favorable impact on hair thickness. Nutrafoods (2020) 1:134-138.
7 Schwartz SR, Park J. Ingestion of BioCell Collagen(®), a unique hydrolyzed rooster sternal cartilage extract; enhanced blood microcirculation and lowered facial getting older indicators. Clin Interv Growing old. 2012;7:267-73.
8 Schwartz SR1, Park J. Ingestion of BioCell Collagen(®), a unique hydrolyzed rooster sternal cartilage extract; enhanced blood microcirculation and lowered facial getting older indicators. Clin Interv Growing old. 2012;7:267-73.
9 Sugihara F, Inoue N. Medical results of collagen hydrolysates ingestion on UV-induced pigmented spots of human pores and skin: A initial find out about. Well being Sciences. 2012;28(2):153-156.
10 Saito N, Tamura T, Morikawa R, Kurihara Ok, Katsuoka Ok. Protection of Meals Containing 5000mg of Collagen Peptide and Its Impact on Hair in Well being Feminine Topics. Aesthet Dermatol. 2008;18:311-320.
11 Koizumi S, Inouse N, Sugihara F. The consequences of collagen hydrolysates derived from tilapia scales or pores and skin on human facial pores and skin. Jap Pharmacology and Therapeutics. 2019; 47(1):57-63.
12 Aguirre A, Gil-Quintana E, Fenaux M, et al. Really helpful Results of Oral Supplementation with Ovoderm on Human Pores and skin Body structure: Two Pilot Research, Magazine of Nutritional Dietary supplements. 2017; DOI: 10.1080/19390211.2017.1310781.
13 Gil-Quintana E, L. a. Nuez M, Aquirre A. Supplementation with Ovoderm Reduces the Medical Indicators of Pores and skin Growing old. A Double-Blind, Placebo-Managed Find out about. Clin Res Dermatol Open Get right of entry to. 2018; 5(2):1-8.
14 Aguirre A, Gil-Quintana E, L. a. Nuez M. Ovoderm an efficient remedy to give a boost to pores and skin situation in sufferers with altered pores and skin barrier serve as. Pores and skin. 2018;2(1):11-14.
15 Blasco JM-I, Aguirre A, Gil-Quintana E, Fenaux M. The impact of day-to-day management of 300 mg of ovomet for remedy of arthritis in aged sufferers. Int J Clin Rheumatol. 2016; 11(5), 77-81.
16 Gil-Quintana E, Fenaux M, L Nuez M, et al. Brief-Time period Results of Ovomet, Eggshell Membrane, in Joint Ache: A Double-Blind and Placebo Find out about. J Osteopor Phys Act. 2018; 6(1):211.